Publications
73. Enantioselective Addition of Bromonitromethane to Aliphatic N-Boc Aldimines Using a Homogeneous Bifunctional Chiral Organocatalyst
Schwieter, K. E. ; Johnston, J. N. ACS Catal. 2015, 5, 6559-6562.
72. A Unified Approach to the Four Azaindoline Families by Inter-/Intramolecular Annulative Diamination of Vinylpyridines
Danneman, M. ; Hong, K. ; Johnston, J. N.
Org. Lett. 2015, 17, 3806-3809.
71. Enantioselective Small Molecule Synthesis by Carbon Dioxide Fixation using a Dual Brønsted Acid Base Organocatalyst Vara, B. ;
Struble, T. ; Wang, W. ; Dobish, M. ; Johnston, J. N. J. Am. Chem. Soc. 2015, 137, 7302-7305.
70. Oxidative Inter-/Intermolecular Alkene Diamination of Hydroxy Styrenes with Electron Rich Amines Danneman, M. ; Hong, K. ; Johnston, J. N.
Org. Lett. 2015, 17, 2558-2561.
69. Enantioselective Synthesis of D-α-Amino Amides from Aliphatic Aldehydes Schwieter, K. E. ; Johnston, J. N. Chem. Sci. 2015, 6, 2590-2595.
Highlighted by Matteo Zanda in Synform 2015, 8, A111
Highlighted by Douglass Taber in Organic Chemistry Portal
68. Adaptation of a Small Molecule Hydrogen Bond-Donor Catalyst to an Enantioselective Hetero-Diels-Alder Reaction Hypothesized for Brevianamide Biosynthesis Sprague, D. ; Nugent, B. M. ; Yoder, R. A. ; Vara, B. ; Johnston, J. N. Org. Lett. 2015, 17, 880-883.
ACS Editor's Choice - Open Access
67. Mdm3 and Aurora Kinase A Inhibitors Synergize to Block Melanoma Growth by Driving Apoptosis and Immune Clearance of Tumor Cells
Vilgelm, A. E. ; Liu, Y. ; Hawkins, O. E. ; Davis, T. ; Smith, J. ; Weller, K. P. ; Horton, L. W. ; McClain, C. M. ; Ayers, G. D. ; Turner, D. C. ; Essaka, D. C. ;
Stewart, C. F. ; Sosman, J. A. ; Kelley, M. C. ; Ecsedy, J. A. ; Johnston, J. N. ; Richmond, A. Cancer Res 2015, 75, 181-193.
66. Brønsted Acid-Catalyzed Phosphoramidic Acid Additions to Alkenes: Diastereo- and Enantioselective Halogenative Cyclizations for the Synthesis of C- and P-Chiral Phosphoramidates Toda, Y. ; Pink, M. ; Johnston, J. N. J. Am. Chem. Soc. 2014, 136, 14734-14737.
65. Umpolung Amide Synthesis Using Substoichiometric NIS and Oxygen as a Terminal Oxidant Schwieter, K. E. ; Shen, B. ; Shackleford, J. ;
Leighty, M. ; Johnston, J. N. Org. Lett. 2014, 16, 4714-4717.
64. Organocatalytic, Diastereo- and Enantioselective Synthesis of Nonsymmetric cis-Stilbene Diamines: A Platform for the Preparation of Single Enantiomer cis-Imidazolines for Protein-Protein Inhibition Vara, B. ; Mayasundari, A. ; Tellis, J. ; Danneman, M. ; Arredondo, V. ; Davis, T. ;
Min, J. ; Finch, K. ; Guy, R. K. ; Johnston, J. N. J. Org. Chem. 2014, 79, 6913-6938.
63. Alkene Diamination Using Electron Rich Amines: Hypervalent Iodine-Promoted Inter/Intramolecular C-N Bond Formation
Hong, K. ; Johnston, J. N. Org. Lett. 2014, 16, 3804-3807.
62. Silyl Imine Electrophiles in Enantioselective Catalysis: A Rosetta Stone for Peptide Homologation, Enabling Diverse N-Protected Aryl Glycines from Aldehydes in Three Steps Makley, D. ; Johnston, J. N. Org. Lett. 2014, 16, 3146-3149.
61. Preparation of (−)-Nutlin-3 Using Enantioselective Organocatalysis at Decagram Scale Davis, T. ; Vilgelm, A. E. ; Richmond, A. ; Johnston, J. N. J. Org. Chem. 2013, 78, 10605-10616.
Highlighted by 'Synthesis of (-)-Nutlin-3' Kocienski, P. Synfacts 2014, 10, 1 [doi: 10.1055/s-0033-1340328]
59. Total Synthesis of the Lycopodium Alkaloid Serratezomine A Using Free Radical-Mediated Vinyl Amination to Prepare a β-Stannyl Enamine Linchpin
Pigza, J. A. ; Han, J. ; Chandra, A. ; Mutnick, D. ; Pink, M. ; Johnston, J. N.
J. Org. Chem. 2013, 78, 822-843.
Selected as JOC Featured Article by Editors
58. VNI cures the acute and chronic experimental Chagas disease Villalta, F. ; Dobish, M. ; Nde, P. N. ; Kleshchenko, Y. Y. ; Hargrove, T. Y. ;
Johnson, C. A. ; Waterman, M. R. ; Johnston, J. N. ; Lepesheva, G. I. J. Infect. Dis. 2013, 208, 504-511.
57. Organocatalytic, Enantioselective Synthesis of VNI: A Robust Therapeutic Development Platform for Chagas, a Neglected Tropical Disease
Dobish, M. ; Villalta, F. ; Waterman, M. R. ; Lepesheva, G. I. ; Johnston, J. N. Org. Lett. 2012, 14, 6322-6325.
Highlighted by 'Synthesis of (+)-VNI' Kocienski, P. Synfacts 2013, 9, 250 [doi: 10.1055/s-0032-1318124]
56. Enantioselective Synthesis of α-Oxy Amides via Umpolung Amide Synthesis Leighty, M. ; Shen, B. ; Johnston, J. N. J. Am. Chem. Soc. 2012,
134, 15233-15236.
Highlighted by 'Synthesis of LY411575' Kocienski, P. Synfacts 2012, 8, 1293 [doi: 10.1055/s-0032-1317560]
55. Chiral Proton Catalysis of Secondary Nitroalkane Additions to Azomethine: Synthesis of a Potent GlyT1 Inhibitor Davis, T. ; Danneman, M.; Johnston, J. N. Chem. Commun. 2012, 48, 5578-5580.
54. Achiral Counterion Control of Enantioselectivity in a Brønsted Acid Catalyzed Iodolactonization Dobish, M. ; Johnston, J. N. J. Am. Chem. Soc.
2012, 134, 6068-6071.
Highlighted by List, Monaco 'Achiral Counteranion Effects in an Asymmetric Iodolactonization' Synfacts, 2012, 8, 673.
52. Umpolung Amide Synthesis: Discovery and Characterization of Anaerobic and Aerobic Pathways to Amide, Introducing an Opportunity for Straightforward Site-Selective 18O–Labeled Peptide Synthesis Shackleford, J. ; Shen, B. ; Johnston, J. N. Proc. Natl. Acad. Sci. 2012, 109, 44-46.
53. Preparation of a Chiral Bis(Amidine) Ligand: Pyrrolidine Bis(Amidine) Davis, T. ; Dobish, M. ; Schwieter, K. E. ; Chun, A. C. ; Johnston, J. N.
Org. Synth. 2012, 89, 380-393.
52. Umpolung Amide Synthesis: Discovery and Characterization of Anaerobic and Aerobic Pathways to Amide, Introducing an Opportunity for Straightforward Site-Selective 18O–Labeled Peptide Synthesis Shackleford, J. ; Shen, B. ; Johnston, J. N. Proc. Natl. Acad. Sci. 2012, 109, 44-46.
51. Total Synthesis of the Chlorine-Containing Hapalindoles K, A, G Chandra, A. ; Johnston, J. N. Angew. Chem. Int. Ed. 2011, 50, 7641-7644.
50. Enantioselective Organocatalysis in the Synthesis of Stilbene cis-Diamines: A Concise Preparation of (–)-Nutlin-3, a Potent p53/MDM2 Inhibitor Davis, T. ; Johnston, J. N. Chem. Sci. 2011, 2, 1076-1079.
Highlighted by Simon Hadlington in Chemistry World 2011 March 25.
Highlighted by Borman, S. 'Chiral Route To Key Anticancer Agent' Chemical & Engineering News, April 11, 2011, 89, 41.
Highlighted by 'Synthetic Protocol Published for Promising Anticancer Compound' Future Medicinal Chemistry 2011, 3, 779.
49. Origins of Selectivity in Brønsted Acid Promoted Diazoalkane-Azomethine Reactions (The aza-Darzens Aziridine Synthesis) Troyer, T. ;
Muchalski, H. ; Hong, K. ; Johnston, J. N. Org. Lett. 2011, 13, 1790-1792.
48. Stereoselective Synthesis of Complex Polycyclic Aziridines: Use of the Brønsted Acid-Promoted aza-Darzens Reaction to Prepare an Orthogonally Protected Mitomycin C Intermediate with Maximal Convergency Srinivasan, J. ; Mathew, P. ; Williams, A. L. ; Huffman, J. C. ;
Johnston, J. N. Chem. Commun. 2011, 47, 3975-3977.
47. Geometric Restraint Drives On- and Off-Pathway Catalysis by the Escherichia Coli Menaquinol:Fumarate Reductase Tomasiak, T.M. ;
Archuleta, T.L. ; Andrell, J. ; Luna-Chavez, C. ; Davis, T. ; Sarwar, M. ; Ham, A.J. ; McDonald, H. ; Yankovskaya, V. ; Stern, H.A. ; Johnston, J. N. ; Maklashina, E. ; Cecchini, G. ; Iverson, T.M. J. Biol. Chem. 2011, 286, 3047-3056.
45. Transformations of Alkenes: Aziridination Muchalski, H. ; Johnston, J. N. Science of Synthesis 2011, 1, 155.
44. A Chiral N-Phosphinyl Phosphoramide: Another Offspring for the Sage Phosphoric Acid Progenitor Johnston, J. N. Angew. Chem. Int. Ed.
2011, 50, 2890-2891.
43. Chiral Brønsted Base-Promoted Nitroalkane Alkylation: Enantioselective Synthesis of Chiral Nonracemic sec-Alkyl-3-Substituted Indoles
Dobish, M. ; Johnston, J. N.
Org. Lett. 2010, 12, 5744-5747.
42. Preparation of Isopropyl 2-Diazoacetyl(phenyl)carbamate Muchalski, H. ; Doody, A. ; Troyer, T. ; Johnston, J. N. Org. Synth. 2011, 88, 212-223.
41. Umpolung Reactivity in Amide and Peptide Synthesis Shen, B. ; Makley, D. ; Johnston, J. N. Nature 2010, 464, 1027-1032.
Highlighted by Jaenicke, L. in Chemie in unserer Zeit 2010, 44, 319
Highlighted in Organic Process Research & Development 2010, 14, 1052-1060 (doi: 10.1021/op100229b)
Highlighted in Chemical & Engineering News, June 28, 2010 Borman, S. 'New Route to Amide Formation'
Highlighted by Scheidt, K. 'Organic chemistry: Amide bonds made in reverse' Nature 2010, 465 , 1020 (doi:10.1038/4651020a)
Highlighted in Pharmaceutical Technology August 2010, Van Arnum, P. 'Exploring Chiral Chemistry'
Highlighted in Pharmaceutical Technology May 2011, Van Arnum, P. 'A Marriage of Small Molecules and Biologics'
40. Bifunctional Asymmetric Catalysis: Amplification of Brønsted Basicity Can Orthogonally Increase the Reactivity of a Chiral Brønsted Acid
Davis, T. ; Wilt, J. C. ; Johnston, J. N. J. Am. Chem. Soc. 2010, 132, 2880-2882.
39. To Protonate or Alkylate: Stereoselective Brønsted Acid Catalysis of Carbon-Carbon Bond Formation Using Diazoalkanes, Leading to Highly Functionalized Chiral Small Molecules Johnston, J. N. ; Muchalski, H. ; Troyer, T. Angew. Chem. Int. Ed. 2010, 49, 2290-2298.
38. A Brønsted Acid Catalyzed syn-Selective Glycolate Mannich Reaction Troyer, T. ; Muchalski, H. ; Johnston, J. N. Chem. Commun.
2009, 41, 6195-6197.
40. Bifunctional Asymmetric Catalysis: Amplification of Brønsted Basicity Can Orthogonally Increase the Reactivity of a Chiral Brønsted Acid
Davis, T. ; Wilt, J. C. ; Johnston, J. N. J. Am. Chem. Soc. 2010, 132, 2880-2882.
40. Bifunctional Asymmetric Catalysis: Amplification of Brønsted Basicity Can Orthogonally Increase the Reactivity of a Chiral Brønsted Acid
Davis, T. ; Wilt, J. C. ; Johnston, J. N. J. Am. Chem. Soc. 2010, 132, 2880-2882.
40. Bifunctional Asymmetric Catalysis: Amplification of Brønsted Basicity Can Orthogonally Increase the Reactivity of a Chiral Brønsted Acid
Davis, T. ; Wilt, J. C. ; Johnston, J. N. J. Am. Chem. Soc. 2010, 132, 2880-2882.
40. Bifunctional Asymmetric Catalysis: Amplification of Brønsted Basicity Can Orthogonally Increase the Reactivity of a Chiral Brønsted Acid
Davis, T. ; Wilt, J. C. ; Johnston, J. N. J. Am. Chem. Soc. 2010, 132, 2880-2882.
40. Bifunctional Asymmetric Catalysis: Amplification of Brønsted Basicity Can Orthogonally Increase the Reactivity of a Chiral Brønsted Acid
Davis, T. ; Wilt, J. C. ; Johnston, J. N. J. Am. Chem. Soc. 2010, 132, 2880-2882.
40. Bifunctional Asymmetric Catalysis: Amplification of Brønsted Basicity Can Orthogonally Increase the Reactivity of a Chiral Brønsted Acid
Davis, T. ; Wilt, J. C. ; Johnston, J. N. J. Am. Chem. Soc. 2010, 132, 2880-2882.
40. Bifunctional Asymmetric Catalysis: Amplification of Brønsted Basicity Can Orthogonally Increase the Reactivity of a Chiral Brønsted Acid
Davis, T. ; Wilt, J. C. ; Johnston, J. N. J. Am. Chem. Soc. 2010, 132, 2880-2882.
40. Bifunctional Asymmetric Catalysis: Amplification of Brønsted Basicity Can Orthogonally Increase the Reactivity of a Chiral Brønsted Acid
Davis, T. ; Wilt, J. C. ; Johnston, J. N. J. Am. Chem. Soc. 2010, 132, 2880-2882.
40. Bifunctional Asymmetric Catalysis: Amplification of Brønsted Basicity Can Orthogonally Increase the Reactivity of a Chiral Brønsted Acid
Davis, T. ; Wilt, J. C. ; Johnston, J. N. J. Am. Chem. Soc. 2010, 132, 2880-2882.
40. Bifunctional Asymmetric Catalysis: Amplification of Brønsted Basicity Can Orthogonally Increase the Reactivity of a Chiral Brønsted Acid
Davis, T. ; Wilt, J. C. ; Johnston, J. N. J. Am. Chem. Soc. 2010, 132, 2880-2882.
53. Preparation of a Chiral Bis(Amidine) Ligand: Pyrrolidine Bis(Amidine) Davis, T. ; Dobish, M. ; Schwieter, K. E. ; Chun, A. C. ; Johnston, J. N.
Org. Synth. 2012, 89, 380-393.
53. Preparation of a Chiral Bis(Amidine) Ligand: Pyrrolidine Bis(Amidine) Davis, T. ; Dobish, M. ; Schwieter, K. E. ; Chun, A. C. ; Johnston, J. N.
Org. Synth. 2012, 89, 380-393.
53. Preparation of a Chiral Bis(Amidine) Ligand: Pyrrolidine Bis(Amidine) Davis, T. ; Dobish, M. ; Schwieter, K. E. ; Chun, A. C. ; Johnston, J. N.
Org. Synth. 2012, 89, 380-393.