Publications
24. A Case Study in Biomimetic Total Synthesis: Polyolefin Carbocyclizations to Terpenes and Steroids
Yoder, R. A. ; Johnston, J. N. Chem. Rev. 2005, 105, 4730-4756.
23. Brønsted Acid-Promoted Olefin Aziridination and Formal anti-Aminohydroxylation
Mahoney, J. M. ; Smith, C. R. ; Johnston, J. N. J. Am. Chem. Soc. 2005, 127, 1354-1355.
22. Free Radical-Mediated Aryl Amination: A Practical Synthesis of (R)- and (S)-7-Azaindoline-α-Amino Acid
Srinivasan, J. ; Burks, H. E. ; Smith, C. R. ; Viswanathan, R. ; Johnston, J. N.
Synthesis 2005, 2, 330-333.
20. IAN-Amines: Chiral C2-Symmetric Zirconium(IV) Complexes from Readily Modified Axially Chiral C1-Symmetric β-Diketimines
Cortright, S. B. ; Huffman, J. C. ; Yoder, R. A. ; Coalter III, J. N. ; Johnston, J. N. Organometallics 2004, 23, 2238-2250.
19. Chiral Proton Catalysis: A Catalytic Enantioselective Direct Aza-Henry Reaction Nugent, B. M. ; Yoder, R. A. ; Johnston, J. N. J. Am. Chem. Soc. 2004, 126, 3418-3419.
Highlighted in Science Concentrates, Chemical & Engineering News, March 22, 2004
18. The Brønsted Acid-Catalyzed Direct Aza-Darzens Synthesis of N-Alkyl cis-Aziridines Williams, A. L. ; Johnston, J. N. J. Am. Chem. Soc. 2004, 126, 1612-1613.
17. Enantioenriched axially chiral β-diketimines: Determination of the ian-amine barrier to atropisomerization Cortright, S. B.;
Yoder, R. A.; Johnston, J. N. Heterocycles 2004, 62, 223-227.
16. Free Radical-Mediated Vinyl Amination: A Mild, General Pyrrolidinyl Enamine Synthesis Nugent, B. M. ; Williams, A. L. ; Prabhakaran, E.;
Johnston, J. N. Tetrahedron 2003, 59, 8877-8888.
15. The First Azacyclopentenyl Carbinyl Radical Isomerizations (ACCRI): Independent Use of Steric and Electronic (Polarization) Effects as Gating Elements Viswanathan, R. ; Mutnick, D. ; Johnston, J. N. J. Am. Chem. Soc. 2003, 125, 7266-7271.
Highlighted in Science & Technology Concentrates, Chemical & Engineering News, June 9, 2003
14. Free Radical-Mediated Aryl Amination and its Use in a Convergent [3+2] Strategy for Enantioselective Indoline α-Amino Acid Synthesis
Viswanathan, R. ; Plotkin, M. A. ; Prabhakaran, E. ; Johnston, J. N. J. Am. Chem. Soc. 2003, 125, 163-168.
13. Free Radical-Mediated Vinyl Amination: Access to N,N-Dialkyl Enamines and their β-Stannyl and β-Thio Derivatives
Prabhakaran, E. ; Williams, A. L. ; Nugent, B. M. ; Nailor, K. E. ; Johnston, J. N. Org. Lett. 2002, 4, 4197-4200.
12. IAN-Amines: Direct Entry to a Chiral C2-Symmetric Zirconium(IV) β-Diketimine Complex
Cortright, S. B. ; Johnston, J. N. Angew. Chem. Int. Ed. 2002, 41, 345-348.
11. Use of the vicinal Element Effect for Regiochemical Control of Quinone Substitutions and its Implication for Convergent Mitomycin Construction Williams, A. L. ; Johnston, J. N. Org. Lett. 2001, 3, 3695-3697.
10. Nonconventional Carbon Additions to Azomethines. Aryl Amination /Indoline Synthesis by Direct Aryl Radical Addition to Azomethine Nitrogen Johnston, J. N. ; Plotkin, M. A. ; Viswanathan, R. ; Prabhakaran, E. Org. Lett. 2001, 3, 1009-1011.
107. A Secondary Orbital Effect Involving Fluorine is Responsible for Substrate-Controlled Diastereodivergence in the syn-aza-Henry Reaction of α-Fluoronitroalkanes Smajlagic, I. ; Johnston, J. N. ; Dudding, T. Chem. Eur. J. 2023, 29 (24), e202204066.
106. Structure-Activity Relationships for the N-Me- versus N-H-Amide Modification to Macrocyclic ent-Verticilide Antiarrhythmics
Smith, A.; Thorpe, M; Blackwell, D; Batiste, S; Hopkins, C; Schley, N; Knollmann, B; Johnston, J. N. ACS Med. Chem. Lett. 2022, 13, 1755-1762.
Featured in the Virtual Collection - Future of Medicinal Chemistry Collection
Don’t miss the Editorial, including statements from Abby (and Jeff) - Special Collection Editorial
105. Preparation of N-Aryl Amides by Epimerization-Free Umpolung Amide Synthesis Crocker, M. S.; Deng, Z. Johnston, J. N. J. Am. Chem. Soc. 2022, 144, 16708-16714.
Featured by Douglass Taber in Org. Chem. Highlights - spectacular reactions
104. Enantioselective Iodolactonization to Prepare ε-Lactone Rings Using Hypervalent Iodine Payne, J.; Deng, Z.; Flach, A.; Johnston, J. N.* [†equal contribution] Chem. Sci. 2022, 13, 7318-7324.
103. Resolving Bromonitromethane Sourcing by Synthesis: Preparation at the Decagram Scale Thorpe, M. P.; Smith, A. N.; Crocker, M. S.;Johnston,
J. N. J. Org. Chem. 2022, 87, 5451-5455.
102. Exercise Causes Arrhythmogenic Remodeling of Intracellular Calcium Dynamics in Plakophilin-2 Deficient Hearts
van Opbergen, C.; Bagwan, N.; Maurya, S; Kim, J.C.; Smith, A; Blackwell, D; Johnston, J.N.; Knollmann, B; Cerrone, M.; Lundby, A; Delmar, M.
Circulation 2022, 145, 1480-1496.
Highlighted in Muscle Cell News
101. Fluorine-Induced Diastereodivergence Discovered in an Equally Rare Enantioselective syn-aza-Henry Reaction
Bing, J. A.; Schley, N. D.; Johnston, J. N. Chem. Sci. 2022, 13, 2614-2623.
100. Ring-Size as an Independent Variable in Cyclooligomeric Depsipeptide Antiarrhythmic Activity
Smith, A. N.; Blackwell, D. J.; Knollmann, B. C.; Johnston, J. N.
ACS Med. Chem. Lett. 2021, 12, 1942-1947.
99. DFT-Based Stereochemical Rationales for the Bifunctional Brønsted Acid/Base-Catalyzed Diastereodivergent and Enantioselective aza-Henry Reactions of α-Nitro Esters Struble, T. J.;† Foy, Hayden;† Dudding, T.*; Johnston, J.N. [†equal contribution] J. Org. Chem. 2021, 86, 15606-15617.
98. The Formation of Impossible Rings in Macrocyclooligomerizations for Cyclodepsipeptide Synthesis: The 18-From-12 Paradox
Smith, A. N.; Johnston, J. N. J. Org. Chem. 2021, 86, 7904-7919.
Related: Batiste, S. M.; Johnston, J. N., Correction to “Evidence for Ion-Templation During Macrocyclooligomerization of Depsipeptides”. J. Am. Chem. Soc. 2021, 143, 6701.
Related: Correction to “Rapid synthesis of cyclic oligomeric depsipeptides with positional, stereochemical, and macrocycle size distribution control” here.
97. RYR2 Channel Inhibition is the Principal Mechanism of Flecainide Action in CPVT
Kryshtal, D. O.; Blackwell, D. J.; Egly, C. L.; Smith, A. N.; Batiste, S. M.; Johnston, J. N.; Laver, D. R.; Knollmann, B. C. Circ. Res. 2021, 128, 321.
